A Secret Weapon For ceesdekker
A Secret Weapon For ceesdekker
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Utilizing single-molecule optical and AFM imaging and pressure-spectroscopy tactics, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our study interests consist of:
But how can morality, the dignity on the human being, my working experience with the that means of lifestyle, follow within the movement of atoms? A purely naturalistic perspective fails below; a Christian standpoint, I believe, is a way more realistic method to interpret these components of fact.’
[Laughs] ‘It absolutely was unquestionably a fantastic risk! At enough time, I was properly aware that it could go Erroneous and that I could develop into much less thriving, but I just dismissed that. Curiosity has normally been my strongest driving power. And luckily all of it labored out.’
Considering the fact that 2000, Dekker has shifted the main focus of his work towards biophysics where he experiments the Attributes of one biomolecules and cells utilizing the instruments of nanotechnology. This modification of subject was driven by his fascination for your outstanding functioning of Organic molecular constructions, and also through the extended-term standpoint that numerous appealing discoveries might be anticipated Within this field.[five] Existing traces of study in his biophysics team are while in the areas of:[six]
2012, discovery that nucleoid occlusion underlies the precision of bacterial mobile division; and to start with ever study on the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
You're a Christian. If you might make such a artificial cell, would you be just one phase nearer to God, or would the position of God have diminished relatively all over again?
Circulation-pushed rotary motors for instance windmills and h2o wheels drive functional processes in human Modern society. Whilst samples of such rotary motors also function prominently in cell biology, their synthetic building on the nanoscale has remained demanding. Below we reveal move-pushed rotary movement of the self-structured DNA nanostructure that may be docked on to a nanopore in a skinny stable-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking onto the sound-condition nanopore, and subsequently displays a sustained unidirectional rotary motion of up to 20 rev s−one.
Imagine if, as an alternative to utilizing common prime-down silicon electronics, transistors might be designed from the bottom up working with single organic and ceesdekker.net natural molecules because the switching features? This idea, which turned the basis of nowadays’s field of molecular electronics, 1st emerged in the nineteen seventies.
Resolving the stage size in condensin-pushed DNA loop extrusion identifies ATP binding since the stage-generating course of action
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of 1st logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA maintenance enzymes with AFM
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2013, controlled shaping of Stay bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations in the handedness of histone tetrasomes